Our technology combines proteins modified with CRISPR-Cas (find module) and PiggyBac transposase (cut-and-transfer module), allowing us to program the precise insertion of small and large fragments of DNA into the genome.
PiggyBac functional domains are engineered to provide increased on-target integration while reducing off-targets events.
FiCAT can be used for in vivo and ex vivo therapies. It also has the potential to tackle prevention and treatment of a wide range of genetic, oncological and autoimmune diseases.